A similar approach is adopted with a binary outcome measure. In a controlled trial of antenatal steroid therapy for neonatal respiratory distress syndrome 27.3% (9/33) of babies born to mothers with pre eclampsia and 14.1% (37/262) of babies born to mothers without pre eclampsia in the control group developed neonatal respiratory distress syndrome; the corresponding figures in the steroid group were 21.2% (7/33) and 7.9% (21/267) respectively.5 Once standard errors of each of these percentages have been found in the usual way4 the method for assessing an interaction between steroid therapy and mother’s pre eclampsia is the same as for continuous outcomes. The treatment effect in babies of mothers with pre eclampsia is 27.3 21.2 = 6.1% (standard error 10.5%) and in babies born to unaffected mothers it is 14.1 7.9 = 6.2% (standard error 2.7%), so the difference in treatment effects is 6.2 6.1 = 0.1% (standard error 10.9%), from which the P value for the difference in treatment effects is P = 0.99..
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